Fixed Bed Bioreactor

A novel spiral wound fixed bed structure enables high.

Fixed bed bioreactor. The icellis single use fixed bed bioreactor is designed to simplify your adherent cell culture process and to provide a scalable path to the commercial manufacturing of virus for vaccine and. To examine the cell distribution in various parts of 4 m 2 fixed bed high compaction bioreactor several bioreactors were disassembled 72 h pt and cell density was analyzed from top middle and bottom part of the bed figure 2b stirring rates were identically increased during inoculations to better distribute cells across the bioreactor bed. The scale x bioreactor portfolio provides enhanced upstream processing of viral products. If properly designed and loaded with a suitable catalyst any fixed bed reactor can be used for hydroprocessing light feeds.

293vec cells were inoculated at 50 000 cells cm 2 with an agitation rate of 1000 rpm during the inoculation phase followed by an agitation rate of 800 rpm during the. To investigate the usage of the fixed bed bioreactors for retroviral vector production we first tested the growth of 293vec packaging cells in the 40 ml c1 bioreactor using 800 ml of working volume without a perfusion loop. There is a wide range of modifications to fixed bed reactors to suit different feeds available commercially. The icellis bioreactor system is an automated single use fixed bed bioreactor that provides excellent cell growth conditions for adherent cells.

Fully integrated single use 500 bioreactor with disposable pre installed calibrated probes. Fixed bed reactors have always been chosen for hydroprocessing distillate feeds. Univercells the scale x is a single use fixed bed bioreactor portfolio for automated scalable bioprocessing of viral vaccines and vectors. In this type of reactor a fluid gas or liquid is passed through a solid granular material usually a catalyst possibly shaped as tiny spheres at high enough speeds to suspend the solid and cause it to behave as though it were a fluid.

Because the matrix on which the cells are growing is fixed the cells have to endure substantially less shear stress while process parameters such as ph and dissolved oxygen can still be tightly controlled. Cell culture process simplification from vial to product. Fixed bed bioreactors or fbbrs are advanced biological wastewater treatment technologies used for efficiently treating wastewaters with high to extremely high organic contamination levels of all biological treatment systems fbbrs can hold the most contaminant eating microbes in the smallest area which makes them space saving and energy efficient technologies ideal for treating wastewaters.